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FERROFOL spansules

UGX 15,000

Description

Ferrofol (Dried ferrous sulphate 150 mg + Equivalent to Iron 47 mg + Folic acid 0.5 mg) 30 capsules

Composition

Each capsule capsule contains:
Dried ferrous sulphate ………………………………………………… 150 mg
Equivalent to Iron ………………………………………………………….. 47 mg
Folic acid ………………………………………………………………………. 0.5 mg

Therapeutic Indications  

Prophylaxis of iron and folic acid deficiency during pregnancy and lactation.
Iron-deficiency anemia.

Dosage and Administration

Adults Only:
One FERROFOL Capsule daily.
Iron-deficiency anemia and some pregnant women may need a higher dose of iron because of dietary or other factors.

Contraindications

Hypersensitivity to any of the ingredients of FERROFOL.
FERROFOL should not be given to patients receiving repeated blood transfusions or to patients with anemias not produced by iron deficiency unless iron deficiency is also present.

Warnings and Precautions 

FERROFOL should never be given for the treatment of undiagnosed megaloblastic anemia, since folic acid may produce a haematopoietic response in patients with a megaloblastic anemia due to vitamin B12 deficiency without preventing aggravation of neurological symptoms, which may lead to serious neurological damage.
FERROFOL should be used with caution in patients with iron-storage or iron-absorption diseases such as haemochromatosis, haemoglobinopathies, or existing gastrointestinal diseases such as inflammatory bowel disease, intestinal strictures and diverticula.

Drug Interactions 

Concurrent use of iron with antacids, calcium supplements, tea, coffee, milk or milk products may decrease iron absorption and so iron supplements should not be taken within one hour before or two hours after ingestion of any of the above.
Concurrent administration of tetracyclines, turpentine with iron salts may impair absorption of both agents, and so if treatment with both drugs is required, a time interval of about 2-3 hours should be allowed between them.
Concomitant administration of penicillamine with iron salts may decrease absorption of penicillamine.
Concomitant administration of folic acid with oral contraceptives, Aminosalicylic may reduce absorption of folic acid.
Concomitant administration of folic acid with antiepileptic drugs such as phenytoin may reduce plasma concentration of these drugs.

Pregnancy and Lactation 

FERROFOL can be used safely during pregnancy and lactation.                                                           

Undesirable Effects        

FERROFOL is generally well–tolerated.
Side effects may include abdominal pain, GI irritation, nausea, vomiting, constipation, diarrhoea, darkening of the stool.

Overdose        

It has been stated that more than the equivalent of 20 mg/kg of iron could lead to some symptoms of toxicity and that in a young child the equivalent of about 60 mg/kg of iron should be regarded as extremely dangerous.
Symptoms:
In the first phase, which occurs up to 6 hours after oral ingestion, gastrointestinal toxicity, notably vomiting and diarrhea, predominates.
Other effects may include cardiovascular disorders such as hypotension, metabolic changes including acidosis and hyperglycemia, and CNS depression ranging from lethargy to coma.
Patients with only mild to moderate poisoning do not generally progress past this first phase.
The second phase, which is not always seen, may occur at 6-24 hours after ingestion and is characterized by a temporary remission or clinical stabilization.
In the third phase, 12-48 hours after ingestion, gastrointestinal toxicity recurs together with shock, metabolic acidosis, severe lethargy or coma, hepatic necrosis and jaundice, hypoglycemia, coagulation disorders, oliguria or renal failure, and possible myocardial dysfunction.
The fourth phase may occur several weeks after ingestion and is characterized by gastrointestinal obstruction and possibly late hepatic damage.
Treatment:
Treatment includes gastric lavage followed by administration of 5 g desferrioxamine by IV infusion. Serum iron levels should be monitored and supportive and symptomatic measures should be applied.                                         

Pharmacological Properties 

FERROFOL is a haematinic preparation especially formulated for prophylaxis and treatment of iron and folic acid deficiency during pregnancy and lactation.
FERROFOL is formulated as capsule capsules to release most of the iron in the upper small intestine where absorption is greatest and not in the stomach where gastric irritation may occur.
Ferrous sulphate acts as a source of iron for iron-deficiency anemia. Each capsule capsule contains 150 mg of dried ferrous sulphate; four-fifths of the iron is especially formulated for sustained release over a period of several hours.
Folic acid is a member of the vitamin B group; it is reduced in the body to tetrahydrofolate, which is a coenzyme for various metabolic processes including the synthesis of DNA.
Both iron and folic acid are essential for erythropoiesis and maturation of RBCs.

Storage            

Store in a dry place at a temperature not exceeding 30°C.

FERROFOL Capsule Capsules:  Box containing 3 strips of 10 capsule capsules each.

 

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