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NEUROZONE Capsule

UGX 36,000

eurozone capsule contains Pregabalin 75mg +Mecobalamin750mcg.

It is well prescribed for the treatment of spinal cord injury-related neuropathic pain, fibromyalgia, perioperative pain, migraine, chronic pain and peripheral neuropathy.
Pregabalin+Mecobalamin can improve energy, memory and learning, supports nervous and immune systems, promotes cardiovascular health, control plasma levels of homocysteine.

Description

Neurozone capsule contains Pregabalin 75mg +Mecobalamin750mcg.

It is well prescribed for the treatment of spinal cord injury-related neuropathic pain, fibromyalgia, perioperative pain, migraine, chronic pain and peripheral neuropathy.
Pregabalin+Mecobalamin can improve energy, memory and learning, supports nervous and immune systems, promotes cardiovascular health, control plasma levels of homocysteine.

Pharmacodynamics

Pregabalin+Mecobalamin can reduce the release of neurotransmitters and promotes regeneration of neuronal myelin sheath. Pregabalin possess analgesic property and reduce neuropathy-related pain symptoms. Mecobalamin is a cofactor of methionine synthase for the transfer of methyl groups to generate methionine from homocysteine. Elevated level of homocysteine is a predominant risk factor of CAD. Methionine can be converted into s-adenosylmethionine, which involve in methylation reactions related to reduction of depressive disorders.

Pregabalin selectively binds to voltage-dependent calcium channel and reduce the release of substance P, glutamate, calcitonin-related peptide and norepinephrine. Contrary to other anxiolytics, Pregabalin neither binds to GABA receptors nor increase/influence GABA currents or metabolism.

Pharmacokinetics
Pregabalin:
After oral administration, Pregabalin is rapidly absorbed in GIT. The Cmax can be achieved within one hour after administration. The oral bioavailability is about 90%. The rate of absorption is influenced by food intake. Pregabalin is not bound to plasma proteins. The Vss of Pregabalin is 0.56L/kg. About 98% of the administered Pregabalin is excreted via the urine as unchanged drug.
Methylcobalamin:
After oral administration, the peak plasma concentration can be achieved after three hours. The vitamin is eliminated in the urine as unchanged drug.

Side Effects:

Constipation,

Drowsiness,

Dry mouth and dizziness,

Somnolence,

Blurring vision.

Precautions

Pregabalin + Mecobalamin should not be prescribed to individuals who are allergic to Pregabalin and vitamin B12 supplements.

Dosage

For adults, take one capsule daily or as directed by a physician

Food(before/after)

Pregabalin + Mecobalamin should be taken before food intake

List of Contraindications

Pregabalin+Mecobalamin and Pregnancy

USFDA pregnancy category C. May be or may not be harmful to an unborn baby. Consult a healthcare provider if you are in gestation or plan to have a baby during Pregabalin + Mecobalamin treatment.

Pregabalin+Mecobalamin and Lactation

It is not known whether Pregabalin + Mecobalamin can pass through the breast milk or not. Nursing mothers should avoid breastfeeding while taking Pregabalin + Mecobalamin.

Storage

Store at 15-30°C. Keep away from light and moisture.

Lab interference

Store at 15-30°C.

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