Rezn zinc sulphate
ReZn tablets contain Zinc, which is an essential element of nutrition and traces are present in a wide range of foods. It is a constituent of many enzyme systems and is present in all tissues. Adequate zinc intake is crucial for health. Zinc deficiency affects cells of the immune system. Zinc sulfate is used to treat and to prevent zinc deficiency.
Zinc supplementation has been shown to be an effective treatment for acute, persistent, and dysenteric diarrhoea in children under five. ReZn tablets are used to reduce morbidity and mortality in children under five with acute, persistent and dysenteric diarrhoea.
Mechanism of Action
Zinc restores mucosal barrier integrity and enterocyte brush-border enzyme activity; it promotes the production of antibodies and circulating lymphocytes against intestinal pathogens, and has a direct effect on ion channels, acting as a potassium channel blocker of adenosine 3-5-cyclic monophosphate-mediated chlorine secretion.
The most frequent adverse effects of zinc salts (the gluconate and sulfate) administered by mouth are gastrointestinal and include abdominal pain, dyspepsia, nausea, vomiting, diarrhoea, gastric irritation, and gastritis. These are particularly common if zinc salts are taken on an empty stomach, and may be reduced by administration with meals.
Drugs which may inhibit zinc absorption, such as penicillamine, sodium valproate and ethambutol, should not be co-administered with ReZn20mg Tablets, unless the risks of discontinuation of the drug are judged to outweigh the benefit of zinc in treatment of the child’s diarrhoea.
ReZn 20mg Tablets contain aspartame, a source of phenylalanine. This should be considered when prescribing the product to patients with phenylketonuria.
The absorption of zinc may be reduced by iron supplements, penicillamine, phosphorus-containing preparations, and tetracyclines. Zinc supplements reduce the absorption of copper, fluoroquinolones, iron, penicillamine, and tetracyclines.
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