Each oft gelatin capsule contains
Inactive ingredients: None Shell
Vitamin E Soft Gelatin Capsules is used in 1 Conditions associated with free radical-induced pathology
- Cystic fibrosis and arthriticise damage Chronic cholestasis.
- in the treatment and prevention of vitamin E deficiency
- One capsule, once daily or as prescribed by the physician, Contraindications in patients with a known hypersensitivity to vitamin E Adverse Effects and precautions Viamin E is usually well tolerated.
- Large doses may cause diarrhea, abdominal pain, and other gastrointestinal disturbances, and have also been reported to cause blurred vision, dizziness,
fatigue and weakness.
- Large doses of vitamin E have been reported to increase bleeding tendency in vitamin-K
deficient patients such as those taking oral anticoagulants. However, it has also been suggested that it may increase the risk of thrombosis in some patients, such as those taking oestrogens, Carcinogenicity It is shown that vitamin E increases incidence of second primary cancers and reduces cancer-free survival in patients with head and neck cancer receiving vitamin E (and betacarotene initially).
- Effect on mortality A study in a population aged 65 years or older, after adjustment for age and sex, found that there was no association between vitamin E use and mortality. However, mortality was increased in vitamin E users who had a history of cardiovascular disease, or who were taking nitrates, warfarin, and diuretics, Mortality in vitamin E users without cardiovascular disease was reduced Studies concluded that vitamin E should be used with caution in those with cardiovascular
disease, and that further investigation of the potential interactions between vitamin E and particular drugs was warranted
- in view of the lack of evidence of benefit with vitamin supplements, it has been recommended
- that the emphasis should instead be on consuming a balanced diet including antoxidant-rich fruits, vegetables, and whole grains rather than vitamin supplements,
Pregnancy and lactation Pregnancy Vitamin E is only recommended for use during pregnancy if clearly needed and only when benefit outweighs risk.
- Vitamin E is distributed into breast milk; however, problems in humans have not been
documented with intake of normal daily recommended amounts.
- Vitamin E substances are classified as not porphyrinogenic, they may be used as drugs
of first choice and no precautions are needed Drug Interactions Various drugs may interfere with the absorption of vitamin E including colestyramine, colestipol.
- High doses of vitamin E may increase the effects of oral anticoagulants.
- Absorption of vitamin E from the gastrointestinal tract is dependent on the presence of bile and on normal pancreatic function. The amount of vitamin E absorbed varies widely between about 20% and 80% and appears to decrease as the dose is increased.
- It enters the blood via the chylomicrons in the lymph and is bound
to beta lipoproteins. It is widely distributed to all tissues, and stored in adipose tissue. Some vitamin E is metabolized in the liver 10 glucuronides of tocopheronic acid and its y-lactone.
- Some is excreted in the urine, but most of a dose is slowly excreted in the bile.
Vitamin E appears in breast milk but is poorly transferred across the placenta.
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